Scientists have in a breakthrough research identified a protein that acts as an “exercise sensor” which is able to detect changes in the blood flow during exercise, a findings that will mimic the positive health benefits of exercise without actually requiring to break a sweat.
According to Study:
- The study found that when the heart pumps more blood in the body during physical activity.
- In addition,the Piezo1 protein in the endothelium or lining of the arteries senses the increased pressure on the wall of the blood vessels.
- In response, it slightly alters the electrical balance in the endothelium and this results in the blood vessels constricting.
- This narrowing of the blood vessels reduces blood flow to the stomach and intestines.
- Furthermore,allowing more blood to reach the brain and muscles actively engaged in exercise.
According to Researchers:
- If we can understand how these systems work.
- Then we may be able to develop techniques that can help tackle some of the biggest diseases afflicting modern societies.
- We know that exercise can protect against heart disease, stroke and many other conditions.
- This study has identified a physiological system that senses when the mammalian body is exercising.
- Furthermore, the researchers investigated the effect of an experimental compound called Yoda1 on the action of the Piezo1 protein.
- They found that it mimicked the action of increasing blood flow on the walls of the endothelium which is experienced during physical activity.
- In addition,raising the possibility that a drug could be developed which enhances the health benefits of exercise.
By modifying Piezo1 protein in the intestines can help move a step closer to having a drug that can help control cardiometabolic syndrome such as cardiovascular disease and Type 2 diabetes, the researchers said.