Carbohydrates could be key to improved malaria vaccine
June, 19 2018 12:21
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Carbohydrates could be key to improved malaria vaccine

By: Shivani Arora

Published on: Sun 17 Sep 2017 06:11 PM

Uttar Pradesh News Portal : Carbohydrates could be key to improved malaria vaccine

Offering vital clues to improving malaria vaccine, an international research team has shown that carbohydrates on the surface of malaria parasites play a critical role in their ability to infect mosquito and human hosts.

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According to a study:

  • The discovery also suggests steps that may improve the only malaria vaccine approved.
  • To protect people against Plasmodium falciparum malaria — the most deadly form of the disease.
  • The team had shown that the malaria parasite “tags” its proteins with carbohydrates in order to stabilise.
  • And transport them and that this process was crucial to completing the parasite’s life cycle.

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According to researchers:

  • Interfering with the parasite’s ability to attach these carbohydrates.
  • To its proteins hinders liver infection and transmission to the mosquito
  • And weakens the parasite to the point that it cannot survive in the host,” said Researchers.
  • Malaria infects over 200 million people worldwide each year and kills around 650,000 people.
  • In addition,predominantly pregnant women and children.
  • Efforts to eradicate malaria require the development of new therapeutics, particularly an effective malaria vaccine.
  • The first malaria vaccine approved for human use -RTS,S/AS01 -got the nod of the European regulators in July 2015.
  • But has not as successful as hoped with marginal efficacy that wanes over time.
  • The new research is aimed at improving malaria vaccine design.
  • With this study, we’ve shown that the parasite protein is tagged with carbohydrates.
  • Furthermore,making it slightly different to the vaccine, so the antibodies produced may not be optimal for recognising target parasites.

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Adding that there were many document cases where attaching carbohydrates to a protein improved its efficacy as a vaccine.

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